Prevalence of off-target effects in Drosophila RNA interference screens

Yong Ma, Adrian Creanga, Lawrence Lum and Philip A. Beachy ()
Additional contact information
Yong Ma: Howard Hughes Medical Institute
Adrian Creanga: Howard Hughes Medical Institute
Lawrence Lum: Howard Hughes Medical Institute
Philip A. Beachy: Howard Hughes Medical Institute

Nature, 2006, vol. 443, issue 7109, 359-363

Abstract: The use of long double-stranded RNAs (dsRNAs) in Drosophila, where Dicer-mediated processing produces small RNAs inside cells, has been thought to reduce the probability of 'off-target effects' (OTEs). However, this study shows that OTEs mediated by short homology stretches within long dsRNAs are prevalent in Drosophila.

Date: 2006
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature05179 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:443:y:2006:i:7109:d:10.1038_nature05179

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05179

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().