Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply)

Niels-Bjarne Woods, Virginie Bottero, Manfred Schmidt, Christof von Kalle and Inder M. Verma ()
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Niels-Bjarne Woods: Laboratory of Genetics, The Salk Institute for Biological Studies
Virginie Bottero: Laboratory of Genetics, The Salk Institute for Biological Studies
Manfred Schmidt: German Cancer Research Center
Christof von Kalle: German Cancer Research Center
Inder M. Verma: Laboratory of Genetics, The Salk Institute for Biological Studies

Nature, 2006, vol. 443, issue 7109, E6-E7

Abstract: Abstract Using a lentiviral vector and a murine model of X-linked severe combined immune deficiency (X-SCID), we have shown that mice transplanted with cells constitutively overexpressing the therapeutic gene IL2RG, a subunit found in several cytokine receptors, can develop thymic lymphomas 6 to 12 months later1. Our results contradict those of Pike-Overzet et al 2and Thrasher et al .3.

Date: 2006
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DOI: 10.1038/nature05220

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