Centrosome polarization delivers secretory granules to the immunological synapse

Jane C. Stinchcombe, Endre Majorovits, Giovanna Bossi, Stephen Fuller and Gillian M. Griffiths ()
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Jane C. Stinchcombe: Sir William Dunn School of Pathology
Endre Majorovits: Wellcome Trust Centre for Human Genetics
Giovanna Bossi: Sir William Dunn School of Pathology
Stephen Fuller: Wellcome Trust Centre for Human Genetics
Gillian M. Griffiths: Sir William Dunn School of Pathology

Nature, 2006, vol. 443, issue 7110, 462-465

Abstract: Special delivery Cytotoxic T lymphocytes are an important part of the immune system, killing targets by releasing the content of secretory lysosomes ('lytic' granules) at the immunological synapse. It's generally assumed that, by analogy to melanocytes, lytic granules travel by short plus-end directed microtubules from the microtubule organizing centre to the actin cytoskeleton in order to reach the immunological synapse. But no. Cytotoxic T lymphocytes have now been found to be independent of actin or plus-end microtubule motors, instead using a novel mechanism controlled by movement of the centrosome to deliver the lethal lytic granules.

Date: 2006
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DOI: 10.1038/nature05071

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