Structural insights into yeast septin organization from polarized fluorescence microscopy

Alina M. Vrabioiu () and Timothy J. Mitchison
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Alina M. Vrabioiu: Harvard Medical School
Timothy J. Mitchison: Harvard Medical School

Nature, 2006, vol. 443, issue 7110, 466-469

Abstract: Hourglass figures There are few analytical methods available for solving cellular structure in the important sub-micrometre range. Alina Vrabioiu and Timothy Mitchison have developed a new one, and used it to resolve a long-standing controversy about the structure of the 'hourglass' feature in dividing yeast cells. Polarized fluorescence microscopy of rigidly attached GFP was used to determine septin filament organization and the dynamics of septin, a polymerizing GTPase intimately involved in cell division. The filaments are seen to form ordered assemblies in living yeast and undergo a 90° rotation before the onset of cytokinesis.

Date: 2006
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DOI: 10.1038/nature05109

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