Increased outcrossing in hothead mutants

Peng Peng, Simon W.-L. Chan, Govind A. Shah and Steve E. Jacobsen ()
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Peng Peng: Howard Hughes Medical Institute, University of California
Simon W.-L. Chan: Cell and Developmental Biology, University of California
Govind A. Shah: Cell and Developmental Biology, University of California
Steve E. Jacobsen: Howard Hughes Medical Institute, University of California

Nature, 2006, vol. 443, issue 7110, E8-E8

Abstract: Abstract Arising from: S. J. Lolle, J. L. Victor, J. M. Young & R. E. Pruitt Nature 434, 505–509 (2005); Lolle et al. reply Lolle et al.1 report that loss-of-function alleles of the HOTHEAD (HTH) gene in Arabidopsis thaliana are genetically unstable, giving rise to wild-type revertants. On the basis of the reversion of many other genetic markers in hth plants, they suggested a model in which a cache of extragenomic information could cause genes to revert to the genotype of previous generations. In our attempts to reproduce this phenomenon, we discovered that hth mutants show a marked tendency to outcross (unlike wild-type A. thaliana, which is almost exclusively self-fertilizing2). Moreover, when hth plants are grown in isolation, their genetic inheritance is completely stable. These results may provide an alternative explanation for the genome wide non-mendelian inheritance reported by Lolle et al.

Date: 2006
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DOI: 10.1038/nature05251

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