Identification of a mammalian mitochondrial porphyrin transporter

Partha C. Krishnamurthy, Guoqing Du, Yu Fukuda, Daxi Sun, Janardhan Sampath, Kelly E. Mercer, Junfeng Wang, Beatriz Sosa-Pineda, K. Gopal Murti and John D. Schuetz ()
Additional contact information
Partha C. Krishnamurthy: Department of Pharmaceutical Sciences
Guoqing Du: Department of Pharmaceutical Sciences
Yu Fukuda: Department of Pharmaceutical Sciences
Daxi Sun: Department of Pharmaceutical Sciences
Janardhan Sampath: Department of Pharmaceutical Sciences
Kelly E. Mercer: Department of Pharmaceutical Sciences
Junfeng Wang: Department of Genetics and Tumor Cell Biology
Beatriz Sosa-Pineda: Department of Genetics and Tumor Cell Biology
K. Gopal Murti: the Scientific Imaging Resource Center, St. Jude Children's Research Hospital
John D. Schuetz: Department of Pharmaceutical Sciences

Nature, 2006, vol. 443, issue 7111, 586-589

Abstract: The transport of porphyrins across the mitochondrial membrane is important for cellular processes. The ABC transporter Abcb6 (an energy-requiring transporter) plays a key role not only in mitochondrial porphyrin transport but also in the upregulation of haeme biosynthesis.

Date: 2006
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DOI: 10.1038/nature05125

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