Reassembly of shattered chromosomes in Deinococcus radiodurans

Ksenija Zahradka, Dea Slade, Adriana Bailone, Suzanne Sommer, Dietrich Averbeck, Mirjana Petranovic, Ariel B. Lindner and Miroslav Radman ()
Additional contact information
Ksenija Zahradka: INSERM Site Necker, U571
Dea Slade: INSERM Site Necker, U571
Adriana Bailone: Institut de Génétique et Microbiologie, CNRS UMR8621, CEA LRC42V, Université Paris-Sud
Suzanne Sommer: Institut de Génétique et Microbiologie, CNRS UMR8621, CEA LRC42V, Université Paris-Sud
Dietrich Averbeck: Institut Curie, Section Recherche, UMR 2027 CNRS, Centre Universitaire de Paris-Sud
Mirjana Petranovic: Ruder Boskovic Institute
Ariel B. Lindner: INSERM Site Necker, U571
Miroslav Radman: INSERM Site Necker, U571

Nature, 2006, vol. 443, issue 7111, 569-573

Abstract: Pull yourself together Deinococcus radiodurans, isolated in the 1950s from canned meat that had gone off despite being sterilized by high-dose radiation, can recover from radiation exposure even though the DNA damage caused completely fragments the genome. How does it achieve this remarkable feat? It is known to carry multiple copies of its genome and quick and effective DNA repair mechanisms. A new study now shows that first, DNA fragments with regions of complementary sequence find each other and initiate synthesis by a DNA polymerase to form long single-stranded ends on the fragments. Then, complementary single-strand tails pair, to regenerate long double-stranded DNA molecules that are processed into the original circular genome.

Date: 2006
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DOI: 10.1038/nature05160

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