Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

John C. Kash (), Terrence M. Tumpey, Sean C. Proll, Victoria Carter, Olivia Perwitasari, Matthew J. Thomas, Christopher F. Basler, Peter Palese, Jeffery K. Taubenberger, Adolfo García-Sastre, David E. Swayne and Michael G. Katze
Additional contact information
John C. Kash: University of Washington School of Medicine
Terrence M. Tumpey: Influenza Branch, DVRD, NCID, Centers for Disease Control and Prevention
Sean C. Proll: Washington National Primate Research Center
Victoria Carter: Washington National Primate Research Center
Olivia Perwitasari: University of Washington School of Medicine
Matthew J. Thomas: Washington National Primate Research Center
Christopher F. Basler: Mount Sinai School of Medicine
Peter Palese: Mount Sinai School of Medicine
Jeffery K. Taubenberger: Armed Forces Institute of Pathology
Adolfo García-Sastre: Mount Sinai School of Medicine
David E. Swayne: Agricultural Research Laboratory, US Department of Agriculture
Michael G. Katze: University of Washington School of Medicine

Nature, 2006, vol. 443, issue 7111, 578-581

Abstract: The 1918 pandemic The availability of a reconstructed 1918 influenza pandemic virus means that it is now possible to study host reactions to the infection, and to use such information to inform public health measures and in the development of new antivirals. A study in mice shows that viruses containing all eight genes from the pandemic strain provoked much greater inflammatory and cell death responses than viruses containing subsets of the genes. This extreme response may be a factor in the severe immunopathology characteristic of the 1918 infection.

Date: 2006
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DOI: 10.1038/nature05181

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