Co-evolution of transcriptional and post-translational cell-cycle regulation

Lars Juhl Jensen, Thomas Skøt Jensen, Ulrik de Lichtenberg, Søren Brunak and Peer Bork ()
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Lars Juhl Jensen: European Molecular Biology Laboratory
Thomas Skøt Jensen: Technical University of Denmark
Ulrik de Lichtenberg: Technical University of Denmark
Søren Brunak: Technical University of Denmark
Peer Bork: European Molecular Biology Laboratory

Nature, 2006, vol. 443, issue 7111, 594-597

Abstract: Time for change Hundreds of genes are transcribed periodically during the cell cycle. The protein complexes involved are much the same among all eukaryotes, but comparison of large-scale microarray data sets from humans, yeasts and plants shows that many different solutions have evolved for assembling the same molecular machinery at the right point in the cell cycle. Transcriptional and post-translational controls evolve in tandem and change is surprisingly rapid in evolutionary terms — over periods of just a few hundred million years. This implies that even within vertebrates, regulatory systems can differ considerably.

Date: 2006
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DOI: 10.1038/nature05186

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