Identification of nesfatin-1 as a satiety molecule in the hypothalamus

Shinsuke Oh-I, Hiroyuki Shimizu, Tetsurou Satoh, Shuichi Okada, Sachika Adachi, Kinji Inoue, Hiroshi Eguchi, Masanori Yamamoto, Toshihiro Imaki, Koushi Hashimoto, Takafumi Tsuchiya, Tsuyoshi Monden, Kazuhiko Horiguchi, Masanobu Yamada and Masatomo Mori ()
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Shinsuke Oh-I: Gunma University Graduate School of Medicine
Hiroyuki Shimizu: Gunma University Graduate School of Medicine
Tetsurou Satoh: Gunma University Graduate School of Medicine
Shuichi Okada: Gunma University Graduate School of Medicine
Sachika Adachi: Saitama University
Kinji Inoue: Saitama University
Hiroshi Eguchi: Teijin Pharma Limited, Asahigaoka
Masanori Yamamoto: Teijin Pharma Limited, Asahigaoka
Toshihiro Imaki: Gunma University Graduate School of Medicine
Koushi Hashimoto: Gunma University Graduate School of Medicine
Takafumi Tsuchiya: Gunma University Graduate School of Medicine
Tsuyoshi Monden: Gunma University Graduate School of Medicine
Kazuhiko Horiguchi: Gunma University Graduate School of Medicine
Masanobu Yamada: Gunma University Graduate School of Medicine
Masatomo Mori: Gunma University Graduate School of Medicine

Nature, 2006, vol. 443, issue 7112, 709-712

Abstract: Enough is enough Appetite is regulated — at least in part — in the hypothalamus, the brain region that links the nervous and endocrine systems. A screen for appetite-regulating molecules has now identified a fragment of the protein nucleobindin 2, dubbed nesfatin-1, as a satiety molecule produced in the hypothalamus. When nesfatin-1 is injected into the brain, rats eat less and lose weight. When nesfatin-1 is blocked, animals eat more. Nesfatin-1 is therefore a possible target for antiobesity drugs.

Date: 2006
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DOI: 10.1038/nature05162

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