The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

Ivan Ahel, Ulrich Rass, Sherif F. El-Khamisy, Sachin Katyal, Paula M. Clements, Peter J. McKinnon, Keith W. Caldecott and Stephen C. West ()
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Ivan Ahel: Cancer Research UK, London Research Institute, Clare Hall Laboratories
Ulrich Rass: Cancer Research UK, London Research Institute, Clare Hall Laboratories
Sherif F. El-Khamisy: University of Sussex
Sachin Katyal: St. Jude Children's Research Hospital
Paula M. Clements: University of Sussex
Peter J. McKinnon: St. Jude Children's Research Hospital
Keith W. Caldecott: University of Sussex
Stephen C. West: Cancer Research UK, London Research Institute, Clare Hall Laboratories

Nature, 2006, vol. 443, issue 7112, 713-716

Abstract: Aprataxin cleans up unfinished DNA ligation intermediates. By cleaving off an adenylate group at the site of a ligatable nick, aprataxin generates ends that can then be re-ligated. This suggests that neurodegeneration results from the accumulation of these intermediates in post-mitotic neuronal cells.

Date: 2006
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DOI: 10.1038/nature05164

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