Phosphoinositides in cell regulation and membrane dynamics

Gilbert Di Paolo () and Pietro De Camilli ()
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Gilbert Di Paolo: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center
Pietro De Camilli: Neurodegeneration and Repair, Howard Hughes Medical Institute and Kavli Institute for Neuroscience, Yale University School of Medicine

Nature, 2006, vol. 443, issue 7112, 651-657

Abstract: Abstract Inositol phospholipids have long been known to have an important regulatory role in cell physiology. The repertoire of cellular processes known to be directly or indirectly controlled by this class of lipids has now dramatically expanded. Through interactions mediated by their headgroups, which can be reversibly phosphorylated to generate seven species, phosphoinositides play a fundamental part in controlling membrane–cytosol interfaces. These lipids mediate acute responses, but also act as constitutive signals that help define organelle identity. Their functions, besides classical signal transduction at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and the permeability and transport functions of membranes.

Date: 2006
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DOI: 10.1038/nature05185

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