Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Yuequan Shen, Andrzej Joachimiak, Marsha Rich Rosner and Wei-Jen Tang ()
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Yuequan Shen: The University of Chicago
Andrzej Joachimiak: Argonne National Laboratory
Marsha Rich Rosner: The University of Chicago
Wei-Jen Tang: The University of Chicago

Nature, 2006, vol. 443, issue 7113, 870-874

Abstract: Amyloid clearance Insulin-degrading enzyme (IDE) is involved in the clearance of insulin and amyloid β. This is necessary to maintain proper blood sugar levels and to prevent accumulation of amyloid β in the brain. The crystal structure of IDE in complex with four substrates has now been determined, revealing the molecular basis for substrate recognition. This should aid the design of IDE-based drugs for Alzheimer's disease and type II diabetes.

Date: 2006
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DOI: 10.1038/nature05143

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