A linguistic model for the rational design of antimicrobial peptides

Christopher Loose, Kyle Jensen, Isidore Rigoutsos and Gregory Stephanopoulos ()
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Christopher Loose: Massachusetts Institute of Technology
Kyle Jensen: Massachusetts Institute of Technology
Isidore Rigoutsos: Massachusetts Institute of Technology
Gregory Stephanopoulos: Massachusetts Institute of Technology

Nature, 2006, vol. 443, issue 7113, 867-869

Abstract: The language of antibiotics Antimicrobial peptides are used by the innate immune system to combat bacterial infection in multicellular eukaryotes, and they show promise as potential therapeutics as they seem less susceptible to bacterial resistance than other antibiotics. A linguistic model has been used to design a series of unnatural antimicrobial peptides with little homology to naturally occurring molecules, but with bacteriostatic activity against several species of bacteria, including Staphylococcus aureus and Bacillus anthracis.

Date: 2006
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DOI: 10.1038/nature05233

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