Amplification of histone genes by circular chromosome formation in Saccharomyces cerevisiae

Diana E. Libuda and Fred Winston ()
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Diana E. Libuda: Harvard Medical School
Fred Winston: Harvard Medical School

Nature, 2006, vol. 443, issue 7114, 1003-1007

Abstract: Making more of genes A previously unknown mechanism for gene amplification has been discovered in the yeast Saccharomyces cerevisiae, involving recombination between transposons that flank a region of the genome that contains histone genes, a centromere, and origins of DNA replication. The transposon sequences physically cross over and recombine as a stable circular chromosome containing the amplified genes. This specific recombination event is enhanced in cells with reduced levels of histones H2A and H2B. Similar mechanisms may be relevant to humans, where 45% of the genome consists of transposons.

Date: 2006
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DOI: 10.1038/nature05205

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