Movement of ‘gating charge’ is coupled to ligand binding in a G-protein-coupled receptor

Yair Ben-Chaim, Baron Chanda, Nathan Dascal, Francisco Bezanilla, Itzchak Parnas and Hanna Parnas ()
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Yair Ben-Chaim: The Hebrew University
Baron Chanda: University of Wisconsin
Nathan Dascal: Tel Aviv University
Francisco Bezanilla: University of Chicago
Itzchak Parnas: The Hebrew University
Hanna Parnas: The Hebrew University

Nature, 2006, vol. 444, issue 7115, 106-109

Abstract: Gate expectations Many extracellular chemical stimuli (hormones, neurotransmitters, odours and so on) are conveyed to the cell via G-protein coupled receptors (GPCRs). First step in these signal transduction processes is binding of ligand to the GPCR. These receptors span the cell membrane, but are not generally considered voltage sensitive. A new study of a prototypical GPCR, the m2 muscarinic receptor, shows that it displays charge movement associated currents analogous to 'gating currents' of voltage-gated channels, and that it is the charge movement that regulates binding affinity of the GPCR. The data indicate that GPCRs act as sensors for both transmembrane potential and external chemical signals.

Date: 2006
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DOI: 10.1038/nature05259

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