Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein

Changjiang Dong, Konstantinos Beis, Jutta Nesper, Anne L. Brunkan-LaMontagne, Bradley R. Clarke, Chris Whitfield and James H. Naismith ()
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Changjiang Dong: The University of St Andrews
Konstantinos Beis: The University of St Andrews
Jutta Nesper: The University of Guelph
Anne L. Brunkan-LaMontagne: The University of Guelph
Bradley R. Clarke: The University of Guelph
Chris Whitfield: The University of Guelph
James H. Naismith: The University of St Andrews

Nature, 2006, vol. 444, issue 7116, 226-229

Abstract: Wza matter Many bacteria possess an external polysaccharide 'capsule' that helps them evade the host immune system and colonize surfaces. As a point of contact between host and pathogen, the capsule is a potential target for vaccines and other therapies. The three-dimensional structure of Wza, a protein responsible for exporting a capsular polysaccharide in Escherichia coli, has now been determined. Most of the protein is located in the periplasm, the space between the inner plasma membrane and the outer cellular membrane, and the protein contains a large central cavity through which the polysaccharide is transported.

Date: 2006
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DOI: 10.1038/nature05267

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