Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

Shinya Yamada, Yasuo Suzuki, Takashi Suzuki, Mai Q. Le, Chairul A. Nidom, Yuko Sakai-Tagawa, Yukiko Muramoto, Mutsumi Ito, Maki Kiso, Taisuke Horimoto, Kyoko Shinya, Toshihiko Sawada, Makoto Kiso, Taiichi Usui, Takeomi Murata, Yipu Lin, Alan Hay, Lesley F. Haire, David J. Stevens, Rupert J. Russell, Steven J. Gamblin, John J. Skehel and Yoshihiro Kawaoka ()
Additional contact information
Shinya Yamada: Division of Virology, Department of Microbiology and Immunology
Yasuo Suzuki: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Takashi Suzuki: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Mai Q. Le: National Institute of Hygiene and Epidemiology
Chairul A. Nidom: Avian Influenza Laboratory, Tropical Disease Centre, Airlangga University
Yuko Sakai-Tagawa: Division of Virology, Department of Microbiology and Immunology
Yukiko Muramoto: Division of Virology, Department of Microbiology and Immunology
Mutsumi Ito: Division of Virology, Department of Microbiology and Immunology
Maki Kiso: Division of Virology, Department of Microbiology and Immunology
Taisuke Horimoto: Division of Virology, Department of Microbiology and Immunology
Kyoko Shinya: Tottori University
Toshihiko Sawada: The United Graduate School of Agricultural Science, Gifu University
Makoto Kiso: The United Graduate School of Agricultural Science, Gifu University
Taiichi Usui: Shizuoka University
Takeomi Murata: Shizuoka University
Yipu Lin: MRC National Institute for Medical Research
Alan Hay: MRC National Institute for Medical Research
Lesley F. Haire: MRC National Institute for Medical Research
David J. Stevens: MRC National Institute for Medical Research
Rupert J. Russell: MRC National Institute for Medical Research
Steven J. Gamblin: MRC National Institute for Medical Research
John J. Skehel: MRC National Institute for Medical Research
Yoshihiro Kawaoka: Division of Virology, Department of Microbiology and Immunology

Nature, 2006, vol. 444, issue 7117, 378-382

Abstract: Pandemic potential The fact that the H5N1 bird flu virus circulating in Asia, Europe and Africa is unable to attach to human-type cell receptors has helped to prevent it from causing a worldwide epidemic of a human variant of the disease. Now a study of H5N1 isolates from some of the few humans that have been infected (from Vietnam and Thailand) has identified two mutations in a viral haemagglutinin that allow it to bind to both human and avian receptors. These mutations might be of use as molecular markers for assessing the pandemic potential of H5N1 field isolates.

Date: 2006
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DOI: 10.1038/nature05264

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