Structural basis for messenger RNA movement on the ribosome

Gulnara Yusupova, Lasse Jenner, Bernard Rees, Dino Moras and Marat Yusupov ()
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Gulnara Yusupova: Institut de Génétique et de Biologie Moléculaire et Cellulaire
Lasse Jenner: Institut de Génétique et de Biologie Moléculaire et Cellulaire
Bernard Rees: Institut de Génétique et de Biologie Moléculaire et Cellulaire
Dino Moras: Institut de Génétique et de Biologie Moléculaire et Cellulaire
Marat Yusupov: Institut de Génétique et de Biologie Moléculaire et Cellulaire

Nature, 2006, vol. 444, issue 7117, 391-394

Abstract: Getting the message Translocation of messenger RNA is one of the most important features of ribosome function and until now a complete structural picture of mRNA movement has been lacking. Now Yusupova et al. describe a series of structures that define how during initiation the mRNA's start codon is recognized, how rotation and movement of the mRNA in the 3′–5′ direction occurs in the post-initiation state, and how mRNA interactions differ during initiation and elongation. This is the first time the mRNA dynamics have been experimentally visualized.

Date: 2006
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DOI: 10.1038/nature05281

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