Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jirina Bartkova (), Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios F. Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis C. Zoumpourlis, Munenori Takaoka, Hiroshi Nakagawa, Frederic Tort, Kasper Fugger, Fredrik Johansson, Maxwell Sehested, Claus L. Andersen, Lars Dyrskjot, Torben Ørntoft, Jiri Lukas, Christos Kittas, Thomas Helleday, Thanos D. Halazonetis (), Jiri Bartek () and Vassilis G. Gorgoulis
Additional contact information
Jirina Bartkova: Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society
Nousin Rezaei: The Wistar Institute
Michalis Liontos: School of Medicine, University of Athens
Panagiotis Karakaidos: School of Medicine, University of Athens
Dimitris Kletsas: Institute of Biology, Demokritos National Center for Scientific Research
Natalia Issaeva: Microbiology and Toxicology, Stockholm University
Leandros-Vassilios F. Vassiliou: School of Medicine, University of Athens
Evangelos Kolettas: School of Medicine, University of Ioannina
Katerina Niforou: School of Medicine, University of Athens
Vassilis C. Zoumpourlis: Institute of Biological Research and Biotechnology, National Hellenic Research Foundation
Munenori Takaoka: University of Pennsylvania
Hiroshi Nakagawa: University of Pennsylvania
Frederic Tort: Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society
Kasper Fugger: Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society
Fredrik Johansson: Microbiology and Toxicology, Stockholm University
Maxwell Sehested: University Hospital
Claus L. Andersen: Aarhus University Hospital
Lars Dyrskjot: Aarhus University Hospital
Torben Ørntoft: Aarhus University Hospital
Jiri Lukas: Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society
Christos Kittas: School of Medicine, University of Athens
Thomas Helleday: Microbiology and Toxicology, Stockholm University
Thanos D. Halazonetis: The Wistar Institute
Jiri Bartek: Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society
Vassilis G. Gorgoulis: School of Medicine, University of Athens

Nature, 2006, vol. 444, issue 7119, 633-637

Abstract: Cancer and cell senescence Cancer is commonly thought of as uncontrolled cellular proliferation, but in the early stages of many cancers, oncogene expression is associated with cellular senescence. A possible explanation for this has now been found. Two groups report a link between oncogene-induced senescence and the DNA damage response. Activated oncogenes can cause aberrant DNA replication and thereby DNA damage that can lead to cell senescence. Cellular senescence was found previously to be a barrier to tumorigenesis in vivo, so oncogene-induced senescence may be an innate defence against cancer. But its effectiveness is often disabled by further mutations. Understanding the relationship between cell senescence and tumour formation may aid in the development of diagnostic and prognostic tools based on senescence markers.

Date: 2006
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DOI: 10.1038/nature05268

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