Protein delivery into eukaryotic cells by type III secretion machines

Jorge E. Galán () and Hans Wolf-Watz
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Jorge E. Galán: Yale University School of Medicine, Boyer Center for Molecular Medicine
Hans Wolf-Watz: Umea University

Nature, 2006, vol. 444, issue 7119, 567-573

Abstract: Proteins to go The type III secretion system (T3SS) is a bacterial organelle that delivers bacterial proteins into eukaryotic cells. First identified in pathogens, genome scanning has revealed these machines in many other bacteria that are symbiotic or pathogenic for animals or plants. Jorge Galán and Hans Wolf-Watz review recent work on the mechanism of T3SS action. Its presence in pathogens makes it a possible target for novel antimicrobial strategies, and these machines might also be harnessed to deliver proteins for therapeutic or vaccine purposes.

Date: 2006
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DOI: 10.1038/nature05272

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