Variability and memory of protein levels in human cells

Alex Sigal, Ron Milo, Ariel Cohen, Naama Geva-Zatorsky, Yael Klein, Yuvalal Liron, Nitzan Rosenfeld, Tamar Danon, Natalie Perzov and Uri Alon ()
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Alex Sigal: Weizmann Institute of Science
Ron Milo: Weizmann Institute of Science
Ariel Cohen: Weizmann Institute of Science
Naama Geva-Zatorsky: Weizmann Institute of Science
Yael Klein: Weizmann Institute of Science
Yuvalal Liron: Weizmann Institute of Science
Nitzan Rosenfeld: Weizmann Institute of Science
Tamar Danon: Weizmann Institute of Science
Natalie Perzov: Weizmann Institute of Science
Uri Alon: Weizmann Institute of Science

Nature, 2006, vol. 444, issue 7119, 643-646

Abstract: Feel the noise Genetically identical cells produce variable levels of a given protein at a given time. This 'noise' in genetic expression is implicated in many important processes including cell fate determination and resistance to drugs. So far the phenomenon has been observed directly only in 'snapshots' of populations of microorganisms. But a study published this week breaks new ground by following the dynamics of such noise over time, in human cancer cells, and comparing different proteins. The work reveals surprisingly long-lasting 'memories' of individual cell states, which can last for more than two generations in culture. This fundamental result may be the basis for human cells' heterogeneous and delayed responses to drugs.

Date: 2006
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DOI: 10.1038/nature05316

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