Centriole assembly in Caenorhabditis elegans

Laurence Pelletier (), Eileen O’Toole, Anne Schwager, Anthony A. Hyman and Thomas Müller-Reichert
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Laurence Pelletier: Max Planck Institute of Molecular Cell Biology and Genetics
Eileen O’Toole: University of Colorado
Anne Schwager: Max Planck Institute of Molecular Cell Biology and Genetics
Anthony A. Hyman: Max Planck Institute of Molecular Cell Biology and Genetics
Thomas Müller-Reichert: Max Planck Institute of Molecular Cell Biology and Genetics

Nature, 2006, vol. 444, issue 7119, 619-623

Abstract: A cell divided Centrioles, rod-shaped organelles vital to replication in most eukaryotic and animal cells, combine a striking 9-fold symmetric structure and an enigmatic mode of replication. The structure of mature centrioles has been extensively studied, but little is known about how they assemble; and though many centriole proteins have been identified, their functions are obscure. Now centriole assembly in C. elegans has been followed ultrastructurally using electron tomography. Assembly starts with formation of a central tube, proceeds via elongation of the tube and finishes with microtubule singlet assembly onto the tube. A pathway for centriole duplication is proposed where SPD-2, ZYG-1 and SAS proteins act sequentially. Some of these proteins are conserved in humans, suggesting that this mechanism also operates in other centriole-bearing organisms. The central image on the cover shows a microtubule singlet assembling onto a daughter centriole tube.

Date: 2006
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DOI: 10.1038/nature05318

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