p63 protects the female germ line during meiotic arrest

Eun-Kyung Suh, Annie Yang, Arminja Kettenbach, Casimir Bamberger, Ala H. Michaelis, Zhou Zhu, Julia A. Elvin, Roderick T. Bronson, Christopher P. Crum and Frank McKeon ()
Additional contact information
Eun-Kyung Suh: Department of Cell Biology
Annie Yang: Department of Cell Biology
Arminja Kettenbach: Department of Cell Biology
Casimir Bamberger: Department of Cell Biology
Ala H. Michaelis: Department of Cell Biology
Zhou Zhu: Department of Genetics
Julia A. Elvin: Brigham and Women’s Hospital
Roderick T. Bronson: Harvard Medical School
Christopher P. Crum: Brigham and Women’s Hospital
Frank McKeon: Department of Cell Biology

Nature, 2006, vol. 444, issue 7119, 624-628

Abstract: Whereas the tumour suppressor gene p53 plays a key role in monitoring and maintaining genomic integrity in somatic cells, it is now shown that in oocytes, a p53 family member, p63 (but not p53 itself), is needed to protect against DNA damage. The specific isoform of p63 that is involved also seems to be the founding member of the p53 family.

Date: 2006
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DOI: 10.1038/nature05337

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