Electrical activity in early neuronal development

Nicholas C. Spitzer ()
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Nicholas C. Spitzer: University of California San Diego

Nature, 2006, vol. 444, issue 7120, 707-712

Abstract: Brain waves The recent discovery that electrical activity has a significant role in embryonic neuronal development introduces a new factor into the study of brain development. Nicholas Spitzer reviews work on the effects of electrical activity on neuronal proliferation, migration and differentiation at the stage of development just after neural induction and before synapse formation. Electrical signalling appears to complement that of genetic programs, and may provide feedback loops to ensure efficient nervous system assembly.

Date: 2006
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DOI: 10.1038/nature05300

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