Klotho converts canonical FGF receptor into a specific receptor for FGF23

Itaru Urakawa (), Yuji Yamazaki, Takashi Shimada, Kousuke Iijima, Hisashi Hasegawa, Katsuya Okawa, Toshiro Fujita, Seiji Fukumoto and Takeyoshi Yamashita
Additional contact information
Itaru Urakawa: Kirin Brewery Co., Ltd
Yuji Yamazaki: Kirin Brewery Co., Ltd
Takashi Shimada: Kirin Brewery Co., Ltd
Kousuke Iijima: Kirin Brewery Co., Ltd
Hisashi Hasegawa: Kirin Brewery Co., Ltd
Katsuya Okawa: Kirin Brewery Co., Ltd
Toshiro Fujita: University of Tokyo Hospital
Seiji Fukumoto: University of Tokyo Hospital
Takeyoshi Yamashita: Kirin Brewery Co., Ltd

Nature, 2006, vol. 444, issue 7120, 770-774

Abstract: Anti-ageing hormone The klotho gene was first identified as a mutation in a mouse strain that exhibits a syndrome resembling human ageing, and overexpression of klotho extends the lifespan of mice. A possible mechanism of action for the Klotho protein has now been found: it converts FGFR1(IIIc), a receptor for various fibroblast growth factors acting at a local level, into a specific receptor for FGF23, a bone-derived hormone that regulates kidney function.

Date: 2006
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DOI: 10.1038/nature05315

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