Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine

Nikolay O. Bukanov, Laurie A. Smith, Katherine W. Klinger, Steven R. Ledbetter and Oxana Ibraghimov-Beskrovnaya ()
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Nikolay O. Bukanov: Cell Biology
Laurie A. Smith: Cell Biology
Katherine W. Klinger: Genetics and Genomics, Genzyme Corporation
Steven R. Ledbetter: Cell Biology
Oxana Ibraghimov-Beskrovnaya: Cell Biology

Nature, 2006, vol. 444, issue 7121, 949-952

Abstract: Targeting cilia Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic condition characterized by the growth of cysts in the kidney tubules and eventual renal failure. As yet there is no effective therapy, but now (R)-roscovitine, a cyclin-dependent kinase inhibitor with anticancer activity, is showing promise in a mouse model of the disease. The drug may be acting via the cilia that line the kidney tubules.

Date: 2006
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DOI: 10.1038/nature05348

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