Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

Corey R. Mandel, Syuzo Kaneko, Hailong Zhang, Damara Gebauer, Vasupradha Vethantham, James L. Manley and Liang Tong ()
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Corey R. Mandel: Columbia University
Syuzo Kaneko: Columbia University
Hailong Zhang: Columbia University
Damara Gebauer: Columbia University
Vasupradha Vethantham: Columbia University
James L. Manley: Columbia University
Liang Tong: Columbia University

Nature, 2006, vol. 444, issue 7121, 953-956

Abstract: The crystal structure of CPSF-73, part of a complex involved in mRNA cleavage and polyadenylation is solved. CPSF-73 was purified and shown to endonucleolytically cleave mRNA, in a reaction mediated by two zinc ligands.

Date: 2006
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DOI: 10.1038/nature05363

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