The cytohesin Steppke is essential for insulin signalling in Drosophila

Bernhard Fuss, Thomas Becker, Ingo Zinke and Michael Hoch ()
Additional contact information
Bernhard Fuss: University of Bonn
Thomas Becker: University of Bonn
Ingo Zinke: University of Bonn
Michael Hoch: University of Bonn

Nature, 2006, vol. 444, issue 7121, 945-948

Abstract: Cytohesins and insulin Insulin resistance syndrome, a condition in which various organs respond insufficiently to insulin, is a major risk factor for the development of type 2 diabetes. For the majority of affected individuals, the underlying molecular defects are unknown. Hafner et al. now show that chemical inhibition of cytohesins, regulatory proteins not previously implicated in insulin-regulated metabolism, induces hepatic insulin resistance in mice. This points to impaired cytohesin function as a possible cause for insulin resistance and to cytohesin activators as a treatment for this disease. In a separate study the Drosophila cytohesin equivalent Steppke is shown to be an essential component of insulin signalling. Taken together, the two papers provide independent evidence for the involvement of cytohesins in the insulin pathway and demonstrate that the cytohesin-mediated control of this pathway is at least 800 million years old.

Date: 2006
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature05412 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05412

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05412

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().