Mechanisms linking obesity to insulin resistance and type 2 diabetes

Steven E. Kahn (), Rebecca L. Hull and Kristina M. Utzschneider
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Steven E. Kahn: Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way
Rebecca L. Hull: Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way
Kristina M. Utzschneider: Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way

Nature, 2006, vol. 444, issue 7121, 840-846

Abstract: Abstract Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet β-cells — the cells that release insulin — failure to control blood glucose levels results. Abnormalities in β-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.

Date: 2006
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DOI: 10.1038/nature05482

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