Inflammation and metabolic disorders

Gökhan S. Hotamisligil ()
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Gökhan S. Hotamisligil: Harvard School of Public Health

Nature, 2006, vol. 444, issue 7121, 860-867

Abstract: Abstract Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.

Date: 2006
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DOI: 10.1038/nature05485

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