Mechanisms linking obesity with cardiovascular disease

Luc F. Van Gaal (), Ilse L. Mertens and Christophe E. De Block
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Luc F. Van Gaal: University of Antwerp, Faculty of Medicine, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10
Ilse L. Mertens: University of Antwerp, Faculty of Medicine, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10
Christophe E. De Block: University of Antwerp, Faculty of Medicine, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10

Nature, 2006, vol. 444, issue 7121, 875-880

Abstract: Abstract Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance — the core feature of type 2 diabetes — as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

Date: 2006
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DOI: 10.1038/nature05487

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