Abdominal obesity and metabolic syndrome

Jean-Pierre Després () and Isabelle Lemieux
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Jean-Pierre Després: Québec Heart Institute, Hôpital Laval Research Centre, 2725 chemin Sainte-Foy, Pavilion Marguerite-D'Youville, 4th Floor
Isabelle Lemieux: Québec Heart Institute, Hôpital Laval Research Centre, 2725 chemin Sainte-Foy, Pavilion Marguerite-D'Youville, 4th Floor

Nature, 2006, vol. 444, issue 7121, 881-887

Abstract: Abstract Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal obesity — the most prevalent manifestation of metabolic syndrome — is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis. Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale.

Date: 2006
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DOI: 10.1038/nature05488

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