Essential role for collectrin in renal amino acid transport

Ursula Danilczyk, Renu Sarao, Christine Remy, Chahira Benabbas, Gerti Stange, Andreas Richter, Sudha Arya, J. Andrew Pospisilik, Dustin Singer, Simone M. R. Camargo, Victoria Makrides, Tamara Ramadan, Francois Verrey, Carsten A. Wagner () and Josef M. Penninger ()
Additional contact information
Ursula Danilczyk: IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences
Renu Sarao: IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences
Christine Remy: University of Zurich
Chahira Benabbas: University of Zurich
Gerti Stange: University of Zurich
Andreas Richter: University of Vienna
Sudha Arya: The Hospital for Sick Children
J. Andrew Pospisilik: IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences
Dustin Singer: University of Zurich
Simone M. R. Camargo: University of Zurich
Victoria Makrides: University of Zurich
Tamara Ramadan: University of Zurich
Francois Verrey: University of Zurich
Carsten A. Wagner: University of Zurich
Josef M. Penninger: IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences

Nature, 2006, vol. 444, issue 7122, 1088-1091

Abstract: Abstract Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals1,2,3. A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been identified in immediate proximity to the ace2 locus4. The in vivo function of collectrin was unclear. Here we report that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney. Collectrin associates with multiple apical transporters and defines a novel group of renal amino acid transporters. Expression of collectrin in Xenopus oocytes and Madin–Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B0AT1. These data identify collectrin as a key regulator of renal amino acid uptake.

Date: 2006
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DOI: 10.1038/nature05475

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