A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Catherine A. O’Brien, Aaron Pollett, Steven Gallinger and John E. Dick ()
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Catherine A. O’Brien: University Health Network
Aaron Pollett: Department of Pathology and Laboratory Medicine
Steven Gallinger: Mount Sinai Hospital
John E. Dick: University Health Network

Nature, 2007, vol. 445, issue 7123, 106-110

Abstract: Cancer stem cells Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells.

Date: 2007
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DOI: 10.1038/nature05372

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