Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

Jean-Antoine Ribeil, Yael Zermati (), Julie Vandekerckhove, Severine Cathelin, Joelle Kersual, Michaël Dussiot, Séverine Coulon, Ivan Cruz Moura, Ann Zeuner, Thomas Kirkegaard-Sørensen, Bruno Varet, Eric Solary, Carmen Garrido and Olivier Hermine ()
Additional contact information
Jean-Antoine Ribeil: Institut Fédérative Necker
Yael Zermati: Institut Fédérative Necker
Julie Vandekerckhove: Institut Fédérative Necker
Severine Cathelin: INSERM UMR 517
Joelle Kersual: Institut Fédérative Necker
Michaël Dussiot: Institut Fédérative Necker
Séverine Coulon: Institut Fédérative Necker
Ivan Cruz Moura: Institut Fédérative Necker
Ann Zeuner: Istituto Superiore di Santia
Thomas Kirkegaard-Sørensen: Institute for Cancer Biology, Danish Cancer Society
Bruno Varet: Institut Fédérative Necker
Eric Solary: INSERM UMR 517
Carmen Garrido: INSERM UMR 517
Olivier Hermine: Institut Fédérative Necker

Nature, 2007, vol. 445, issue 7123, 102-105

Abstract: The heat-shock protein Hsp70 can regulate the development of red blood cells, or erythropoiesis. Hsp70 interacts with GATA-1 and protects it from cleavage, thus controlling the differentiation of erythrocytes by its presence in the nucleus.

Date: 2007
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DOI: 10.1038/nature05378

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