A systems biology analysis of the Drosophila phagosome

L. M. Stuart (), J. Boulais, G. M. Charriere, E. J. Hennessy, S. Brunet, I. Jutras, G. Goyette, C. Rondeau, S. Letarte, H. Huang, P. Ye, F. Morales, C. Kocks, J. S. Bader, M. Desjardins and R. A. B. Ezekowitz
Additional contact information
L. M. Stuart: Massachusetts General Hospital/ Harvard Medical School
J. Boulais: Université de Montréal
G. M. Charriere: Massachusetts General Hospital/ Harvard Medical School
E. J. Hennessy: Massachusetts General Hospital/ Harvard Medical School
S. Brunet: Université de Montréal
I. Jutras: Université de Montréal
G. Goyette: Université de Montréal
C. Rondeau: Université de Montréal
S. Letarte: Université de Montréal
H. Huang: Johns Hopkins University
P. Ye: Johns Hopkins University
F. Morales: McGill University
C. Kocks: Massachusetts General Hospital/ Harvard Medical School
J. S. Bader: Johns Hopkins University
M. Desjardins: Université de Montréal
R. A. B. Ezekowitz: Massachusetts General Hospital/ Harvard Medical School

Nature, 2007, vol. 445, issue 7123, 95-101

Abstract: Anatomy of the phagosome The phagocytes in our blood-stream are central to our defence against pathogens: they bind and internalize bacteria into a subcellular compartment termed the phagosome where they are destroyed. Some pathogens have evolved strategies to evade this process, so a better understanding of how phagocytosis is regulated is important for the study of host–pathogen interactions and innate immunity. Using a systems biology approach, Stuart et al. identified over 600 phagosome-related proteins in Drosophila, and analysed many of the proteins' complex interactions. The result is a detailed model of the phagosome and regulators of bacterial engulfment.

Date: 2007
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DOI: 10.1038/nature05380

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