Identification and expansion of human colon-cancer-initiating cells

Lucia Ricci-Vitiani, Dario G. Lombardi, Emanuela Pilozzi, Mauro Biffoni, Matilde Todaro, Cesare Peschle and Ruggero De Maria ()
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Lucia Ricci-Vitiani: Istituto Superiore di Sanità
Dario G. Lombardi: Mediterranean Institute of Oncology
Emanuela Pilozzi: University ‘La Sapienza’
Mauro Biffoni: Istituto Superiore di Sanità
Matilde Todaro: University of Palermo
Cesare Peschle: Istituto Superiore di Sanità
Ruggero De Maria: Istituto Superiore di Sanità

Nature, 2007, vol. 445, issue 7123, 111-115

Abstract: Cancer stem cells Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells.

Date: 2007
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DOI: 10.1038/nature05384

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