Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

Cathy Haag-Liautard, Mark Dorris, Xulio Maside, Steven Macaskill, Daniel L. Halligan, Brian Charlesworth and Peter D. Keightley ()
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Cathy Haag-Liautard: University of Edinburgh
Mark Dorris: University of Edinburgh
Xulio Maside: University of Edinburgh
Steven Macaskill: University of Edinburgh
Daniel L. Halligan: University of Edinburgh
Brian Charlesworth: University of Edinburgh
Peter D. Keightley: University of Edinburgh

Nature, 2007, vol. 445, issue 7123, 82-85

Abstract: Mutation by numbers Many theoretical calculations in genetics rely on an estimate of u, the mutation rate per nucleotide in the genome, but its value has been controversial because only indirect estimates have previously been available. For the first time a direct estimate of the mutation rate per base pair has been obtained in Drosophila, based on scanning the genome of mutation accumulation lines for mutational changes in the DNA. The new estimate is relatively high, implying that selection against deleterious mutations favours the evolution of sex and recombination.

Date: 2007
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DOI: 10.1038/nature05388

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