Hodgkin and Huxley model — still standing? (Reply)

Björn Naundorf, Fred Wolf () and Maxim Volgushev
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Björn Naundorf: Max Planck Institute for Dynamics and Self-Organization, University of Göttingen
Fred Wolf: Max Planck Institute for Dynamics and Self-Organization, University of Göttingen
Maxim Volgushev: Ruhr-University Bochum

Nature, 2007, vol. 445, issue 7123, E2-E3

Abstract: Abstract McCormick et al. 1 question whether the rapid onset and highly variable thresholds of action potentials2 are genuine features of cortical action-potential generators — that is, whether they reflect the voltage-dependence of the underlying sodium currents. Instead, they consider these features to be epiphenomena, reflecting lateral currents from a remote initiation site, and, contrary to direct evidence3, they assume that sodium currents show canonical kinetics.

Date: 2007
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DOI: 10.1038/nature05534

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