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Helen Dell

Nature, 2007, vol. 445, issue 7124, 157-157

Abstract: Early developers The assumption that the cells of the mammalian embryo are identical until they form into 'inside' and 'outside' cells was overturned by the recent discovery that cells in the mouse differ in cell fate from as early as the four-cell stage. An epigenetic (non-DNA coded) mechanism seemed likely, and that has now been shown to be the case. Differential epigenetic modification (arginine methylation) of histone H3 in the four-cell mouse blastomere changes the fate of embryo cells and can maintain a cell in a pluripotent state.

Date: 2007
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DOI: 10.1038/445157a

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