A stomatin-domain protein essential for touch sensation in the mouse

Christiane Wetzel, Jing Hu, Dieter Riethmacher, Anne Benckendorff, Lena Harder, Andreas Eilers, Rabih Moshourab, Alexey Kozlenkov, Dominika Labuz, Ombretta Caspani, Bettina Erdmann, Halina Machelska, Paul A. Heppenstall and Gary R. Lewin ()
Additional contact information
Christiane Wetzel: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Jing Hu: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Dieter Riethmacher: Universität Hamburg
Anne Benckendorff: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Lena Harder: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Andreas Eilers: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Rabih Moshourab: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Alexey Kozlenkov: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Dominika Labuz: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin
Ombretta Caspani: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin
Bettina Erdmann: Electronmicroscopy, Max-Delbrück Center for Molecular Medicine
Halina Machelska: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin
Paul A. Heppenstall: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
Gary R. Lewin: Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin

Nature, 2007, vol. 445, issue 7124, 206-209

Abstract: Touch base The sense of touch is mediated by the many mechanoreceptors present in the skin. Now, for first time in a vertebrate, a single molecule whose function is necessary for this primary transduction event has been identified. The membrane protein SLP3 is necessary for mechanoreceptor function in mice in vivo, and is also required for mechanosensitive channels to function. SLP3 also modulates ion channels previously implicated in touch sensation, so may be a subunit of the mammalian touch transducer.

Date: 2007
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DOI: 10.1038/nature05394

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