Genome-wide atlas of gene expression in the adult mouse brain

Lein, Ed S.; Hawrylycz, Michael J.; Ao, Nancy; Ayres, Mikael; Bensinger, Amy; Bernard, Amy; Boe, Andrew F.; Boguski, Mark S.; Brockway, Kevin S.; Byrnes, Emi J.; Chen, Lin; Chen, Li; Chen, Tsuey-Ming; Chin, Mei Chi; Chong, Jimmy; Crook, Brian E.; Czaplinska, Aneta; Dang, Chinh N.; Datta, Suvro; Dee, Nick R.; Desaki, Aimee L.; Desta, Tsega; Diep, Ellen; Dolbeare, Tim A.; Donelan, Matthew J.; Dong, Hong-Wei; Dougherty, Jennifer G.; Duncan, Ben J.; Ebbert, Amanda J.; Eichele, Gregor; Estin, Lili K.; Faber, Casey; Facer, Benjamin A.; Fields, Rick; Fischer, Shanna R.; Fliss, Tim P.; Frensley, Cliff; Gates, Sabrina N.; Glattfelder, Katie J.; Halverson, Kevin R.; Hart, Matthew R.; Hohmann, John G.; Howell, Maureen P.; Jeung, Darren P.; Johnson, Rebecca A.; Karr, Patrick T.; Kawal, Reena; Kidney, Jolene M.; Knapik, Rachel H.; Kuan, Chihchau L.; Lake, James H.; Laramee, Annabel R.; Larsen, Kirk D.; Lau, Christopher; Lemon, Tracy A.; Liang, Agnes J.; Liu, Ying; Luong, Lon T.; Michaels, Jesse; Morgan, Judith J.; Morgan, Rebecca J.; Mortrud, Marty T.; Mosqueda, Nerick F.; Ng, Lydia L.; Ng, Randy; Orta, Geralyn J.; Overly, Caroline C.; Pak, Tu H.; Parry, Sheana E.; Pathak, Sayan D.; Pearson, Owen C.; Puchalski, Ralph B.; Riley, Zackery L.; Rockett, Hannah R.; Rowland, Stephen A.; Royall, Joshua J.; Ruiz, Marcos J.; Sarno, Nadia R.; Schaffnit, Katherine; Shapovalova, Nadiya V.; Sivisay, Taz; Slaughterbeck, Clifford R.; Smith, Simon C.; Smith, Kimberly A.; Smith, Bryan I.; Sodt, Andy J.; Stewart, Nick N.; Stumpf, Kenda-Ruth; Sunkin, Susan M.; Sutram, Madhavi; Tam, Angelene; Teemer, Carey D.; Thaller, Christina; Thompson, Carol L.; Varnam, Lee R.; Visel, Axel; Whitlock, Ray M.; Wohnoutka, Paul E.; Wolkey, Crissa K.; Wong, Victoria Y.; Wood, Matthew; Yaylaoglu, Murat B.; Young, Rob C.; Youngstrom, Brian L.; Yuan, Xu Feng; Zhang, Bin; Zwingman, Theresa A.; Jones, Allan R.

Genome-wide atlas of gene expression in the adult mouse brain

Ed S. Lein (), Michael J. Hawrylycz, Nancy Ao, Mikael Ayres, Amy Bensinger, Amy Bernard, Andrew F. Boe, Mark S. Boguski, Kevin S. Brockway, Emi J. Byrnes, Lin Chen, Li Chen, Tsuey-Ming Chen, Mei Chi Chin, Jimmy Chong, Brian E. Crook, Aneta Czaplinska, Chinh N. Dang, Suvro Datta, Nick R. Dee, Aimee L. Desaki, Tsega Desta, Ellen Diep, Tim A. Dolbeare, Matthew J. Donelan, Hong-Wei Dong, Jennifer G. Dougherty, Ben J. Duncan, Amanda J. Ebbert, Gregor Eichele, Lili K. Estin, Casey Faber, Benjamin A. Facer, Rick Fields, Shanna R. Fischer, Tim P. Fliss, Cliff Frensley, Sabrina N. Gates, Katie J. Glattfelder, Kevin R. Halverson, Matthew R. Hart, John G. Hohmann, Maureen P. Howell, Darren P. Jeung, Rebecca A. Johnson, Patrick T. Karr, Reena Kawal, Jolene M. Kidney, Rachel H. Knapik, Chihchau L. Kuan, James H. Lake, Annabel R. Laramee, Kirk D. Larsen, Christopher Lau, Tracy A. Lemon, Agnes J. Liang, Ying Liu, Lon T. Luong, Jesse Michaels, Judith J. Morgan, Rebecca J. Morgan, Marty T. Mortrud, Nerick F. Mosqueda, Lydia L. Ng, Randy Ng, Geralyn J. Orta, Caroline C. Overly, Tu H. Pak, Sheana E. Parry, Sayan D. Pathak, Owen C. Pearson, Ralph B. Puchalski, Zackery L. Riley, Hannah R. Rockett, Stephen A. Rowland, Joshua J. Royall, Marcos J. Ruiz, Nadia R. Sarno, Katherine Schaffnit, Nadiya V. Shapovalova, Taz Sivisay, Clifford R. Slaughterbeck, Simon C. Smith, Kimberly A. Smith, Bryan I. Smith, Andy J. Sodt, Nick N. Stewart, Kenda-Ruth Stumpf, Susan M. Sunkin, Madhavi Sutram, Angelene Tam, Carey D. Teemer, Christina Thaller, Carol L. Thompson, Lee R. Varnam, Axel Visel, Ray M. Whitlock, Paul E. Wohnoutka, Crissa K. Wolkey, Victoria Y. Wong, Matthew Wood, Murat B. Yaylaoglu, Rob C. Young, Brian L. Youngstrom, Xu Feng Yuan, Bin Zhang, Theresa A. Zwingman and Allan R. Jones ()
Additional contact information
Ed S. Lein: Allen Institute for Brain Science
Michael J. Hawrylycz: Allen Institute for Brain Science
Nancy Ao: Baylor College of Medicine
Mikael Ayres: Allen Institute for Brain Science
Amy Bensinger: Allen Institute for Brain Science
Amy Bernard: Allen Institute for Brain Science
Andrew F. Boe: Allen Institute for Brain Science
Mark S. Boguski: Allen Institute for Brain Science
Kevin S. Brockway: Allen Institute for Brain Science
Emi J. Byrnes: Allen Institute for Brain Science
Lin Chen: Allen Institute for Brain Science
Li Chen: Baylor College of Medicine
Tsuey-Ming Chen: Baylor College of Medicine
Mei Chi Chin: Allen Institute for Brain Science
Jimmy Chong: Allen Institute for Brain Science
Brian E. Crook: Allen Institute for Brain Science
Aneta Czaplinska: Baylor College of Medicine
Chinh N. Dang: Allen Institute for Brain Science
Suvro Datta: Allen Institute for Brain Science
Nick R. Dee: Allen Institute for Brain Science
Aimee L. Desaki: Allen Institute for Brain Science
Tsega Desta: Allen Institute for Brain Science
Ellen Diep: Allen Institute for Brain Science
Tim A. Dolbeare: Allen Institute for Brain Science
Matthew J. Donelan: Allen Institute for Brain Science
Hong-Wei Dong: Allen Institute for Brain Science
Jennifer G. Dougherty: Allen Institute for Brain Science
Ben J. Duncan: Allen Institute for Brain Science
Amanda J. Ebbert: Allen Institute for Brain Science
Gregor Eichele: Max Planck Institute of Biophysical Chemistry
Lili K. Estin: Allen Institute for Brain Science
Casey Faber: Allen Institute for Brain Science
Benjamin A. Facer: Allen Institute for Brain Science
Rick Fields: Baylor College of Medicine
Shanna R. Fischer: Allen Institute for Brain Science
Tim P. Fliss: Allen Institute for Brain Science
Cliff Frensley: Allen Institute for Brain Science
Sabrina N. Gates: Allen Institute for Brain Science
Katie J. Glattfelder: Allen Institute for Brain Science
Kevin R. Halverson: Allen Institute for Brain Science
Matthew R. Hart: Allen Institute for Brain Science
John G. Hohmann: Allen Institute for Brain Science
Maureen P. Howell: Allen Institute for Brain Science
Darren P. Jeung: Allen Institute for Brain Science
Rebecca A. Johnson: Allen Institute for Brain Science
Patrick T. Karr: Allen Institute for Brain Science
Reena Kawal: Allen Institute for Brain Science
Jolene M. Kidney: Allen Institute for Brain Science
Rachel H. Knapik: Allen Institute for Brain Science
Chihchau L. Kuan: Allen Institute for Brain Science
James H. Lake: Allen Institute for Brain Science
Annabel R. Laramee: Allen Institute for Brain Science
Kirk D. Larsen: Allen Institute for Brain Science
Christopher Lau: Allen Institute for Brain Science
Tracy A. Lemon: Allen Institute for Brain Science
Agnes J. Liang: Baylor College of Medicine
Ying Liu: Baylor College of Medicine
Lon T. Luong: Allen Institute for Brain Science
Jesse Michaels: Allen Institute for Brain Science
Judith J. Morgan: Allen Institute for Brain Science
Rebecca J. Morgan: Allen Institute for Brain Science
Marty T. Mortrud: Allen Institute for Brain Science
Nerick F. Mosqueda: Allen Institute for Brain Science
Lydia L. Ng: Allen Institute for Brain Science
Randy Ng: Allen Institute for Brain Science
Geralyn J. Orta: Allen Institute for Brain Science
Caroline C. Overly: Allen Institute for Brain Science
Tu H. Pak: Allen Institute for Brain Science
Sheana E. Parry: Allen Institute for Brain Science
Sayan D. Pathak: Allen Institute for Brain Science
Owen C. Pearson: Allen Institute for Brain Science
Ralph B. Puchalski: Allen Institute for Brain Science
Zackery L. Riley: Allen Institute for Brain Science
Hannah R. Rockett: Allen Institute for Brain Science
Stephen A. Rowland: Allen Institute for Brain Science
Joshua J. Royall: Allen Institute for Brain Science
Marcos J. Ruiz: Baylor College of Medicine
Nadia R. Sarno: Allen Institute for Brain Science
Katherine Schaffnit: Allen Institute for Brain Science
Nadiya V. Shapovalova: Allen Institute for Brain Science
Taz Sivisay: Allen Institute for Brain Science
Clifford R. Slaughterbeck: Allen Institute for Brain Science
Simon C. Smith: Allen Institute for Brain Science
Kimberly A. Smith: Allen Institute for Brain Science
Bryan I. Smith: Allen Institute for Brain Science
Andy J. Sodt: Allen Institute for Brain Science
Nick N. Stewart: Allen Institute for Brain Science
Kenda-Ruth Stumpf: Allen Institute for Brain Science
Susan M. Sunkin: Allen Institute for Brain Science
Madhavi Sutram: Allen Institute for Brain Science
Angelene Tam: Baylor College of Medicine
Carey D. Teemer: Allen Institute for Brain Science
Christina Thaller: Baylor College of Medicine
Carol L. Thompson: Allen Institute for Brain Science
Lee R. Varnam: Allen Institute for Brain Science
Axel Visel: Max Planck Institute of Biophysical Chemistry
Ray M. Whitlock: Allen Institute for Brain Science
Paul E. Wohnoutka: Allen Institute for Brain Science
Crissa K. Wolkey: Allen Institute for Brain Science
Victoria Y. Wong: Allen Institute for Brain Science
Matthew Wood: Baylor College of Medicine
Murat B. Yaylaoglu: Baylor College of Medicine
Rob C. Young: Allen Institute for Brain Science
Brian L. Youngstrom: Allen Institute for Brain Science
Xu Feng Yuan: Allen Institute for Brain Science
Bin Zhang: Baylor College of Medicine
Theresa A. Zwingman: Allen Institute for Brain Science
Allan R. Jones: Allen Institute for Brain Science

Nature, 2007, vol. 445, issue 7124, 168-176

Abstract: Abstract Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function.

Date: 2007
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DOI: 10.1038/nature05453

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