Histone arginine methylation regulates pluripotency in the early mouse embryo

Maria-Elena Torres-Padilla, David-Emlyn Parfitt, Tony Kouzarides and Magdalena Zernicka-Goetz ()
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Maria-Elena Torres-Padilla: University of Cambridge
David-Emlyn Parfitt: University of Cambridge
Tony Kouzarides: University of Cambridge
Magdalena Zernicka-Goetz: University of Cambridge

Nature, 2007, vol. 445, issue 7124, 214-218

Abstract: Early developers The assumption that the cells of the mammalian embryo are identical until they form into 'inside' and 'outside' cells was overturned by the recent discovery that cells in the mouse differ in cell fate from as early as the four-cell stage. An epigenetic (non-DNA coded) mechanism seemed likely, and that has now been shown to be the case. Differential epigenetic modification (arginine methylation) of histone H3 in the four-cell mouse blastomere changes the fate of embryo cells and can maintain a cell in a pluripotent state.

Date: 2007
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DOI: 10.1038/nature05458

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