Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

J. P. J. Saeij, S. Coller, J. P. Boyle, M. E. Jerome, M. W. White and J. C. Boothroyd ()
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J. P. J. Saeij: Stanford University School of Medicine
S. Coller: Stanford University School of Medicine
J. P. Boyle: Stanford University School of Medicine
M. E. Jerome: Montana State University
M. W. White: Montana State University
J. C. Boothroyd: Stanford University School of Medicine

Nature, 2007, vol. 445, issue 7125, 324-327

Abstract: Degrees of toxoplasmosis The protozoon Toxoplasma gondii causes intracellular infections with extraordinary differences in disease severity, ranging from inevitable death to a mild chronic infection. The reason for this variation has been something of a mystery, but an enzyme that could be responsible has now been identified. Toxoplasma injects a protein kinase into the host cell that is rapidly transported to the nucleus where it dramatically alters host gene expression, including genes that determine the host response to infection. Different Toxoplasma strains have different versions of this protein, and this could explain the wide variations in pathogenicity.

Date: 2007
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DOI: 10.1038/nature05395

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