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Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning

Randall D. Dahn, Marcus C. Davis, William N. Pappano and Neil H. Shubin ()
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Randall D. Dahn: The University of Chicago
Marcus C. Davis: The University of Chicago
William N. Pappano: The Johns Hopkins School of Medicine
Neil H. Shubin: The University of Chicago

Nature, 2007, vol. 445, issue 7125, 311-314

Abstract: Out on a fin A key question in the evolution of limbs and fins is the generality of the genetic mechanism underlying their development. Following reports that shark fins developed without Sonic hedgehog (Shh), a gene elsewhere seen as crucial to the process, Dahn et al. re-investigated the problem. They find that Shh is indeed involved in shark fin development, boosting its credentials as a key component of anteroposterior patterning of vertebrate fins and limbs.

Date: 2007
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DOI: 10.1038/nature05436

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