CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

Seiji Tanaka, Toshiko Umemori, Kazuyuki Hirai, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki ()
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Seiji Tanaka: National Institute of Genetics, Research Organization of Information and Systems
Toshiko Umemori: National Institute of Genetics, Research Organization of Information and Systems
Kazuyuki Hirai: National Institute of Genetics, Research Organization of Information and Systems
Sachiko Muramatsu: National Institute of Genetics, Research Organization of Information and Systems
Yoichiro Kamimura: National Institute of Genetics, Research Organization of Information and Systems
Hiroyuki Araki: National Institute of Genetics, Research Organization of Information and Systems

Nature, 2007, vol. 445, issue 7125, 328-332

Abstract: This paper, one of two published that show Sld2 and Sld3 constitute the minimal group of cyclin-dependent kinase (CDK) targets necessary to promote replication, also finds that the function of G1 CDKs in replication is not just to activate the S-phase CDKs, but also to regulate the Cdc7 kinase regulatory subunit, Dbf4.

Date: 2007
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DOI: 10.1038/nature05465

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