Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

Darwyn Kobasa, Steven M. Jones, Kyoko Shinya, John C. Kash, John Copps, Hideki Ebihara, Yasuko Hatta, Jin Hyun Kim, Peter Halfmann, Masato Hatta, Friederike Feldmann, Judie B. Alimonti, Lisa Fernando, Yan Li, Michael G. Katze, Heinz Feldmann and Yoshihiro Kawaoka ()
Additional contact information
Darwyn Kobasa: Public Health Agency of Canada
Steven M. Jones: Public Health Agency of Canada
Kyoko Shinya: Tottori University
John C. Kash: University of Washington
John Copps: Canadian Food Inspection Agency, Canadian Science Centre for Human and Animal Health
Hideki Ebihara: Public Health Agency of Canada
Yasuko Hatta: University of Wisconsin-Madison
Jin Hyun Kim: University of Wisconsin-Madison
Peter Halfmann: University of Wisconsin-Madison
Masato Hatta: University of Wisconsin-Madison
Friederike Feldmann: Public Health Agency of Canada
Judie B. Alimonti: Public Health Agency of Canada
Lisa Fernando: Public Health Agency of Canada
Yan Li: Public Health Agency of Canada
Michael G. Katze: University of Washington
Heinz Feldmann: Public Health Agency of Canada
Yoshihiro Kawaoka: University of Tokyo

Nature, 2007, vol. 445, issue 7125, 319-323

Abstract: The deadly 1918 flu virus The 1918 'Spanish flu' influenza pandemic was unusually severe, causing about 50 million deaths. Why was it so destructive? The lack of antibiotics to fight secondary infections, and socioeconomic factors may be relevant. But experimental infection of nonhuman primates with reconstructed 1918 virus suggests that the lethal nature of the virus itself was a big factor. It is in fact the only influenza virus lethal to experimentally infected nonhuman primates, and the 1918 virus, unlike other strains, suppresses innate immune responses. The H5N1 viruses now circulating cause a severe lung infection similar to that caused by the 1918 virus and also suppress innate immunity, so therapies that protect this type of host immunity might reduce the severity of infection due to these influenza viruses.

Date: 2007
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DOI: 10.1038/nature05495

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