Label-free immunodetection with CMOS-compatible semiconducting nanowires

Eric Stern, James F. Klemic, David A. Routenberg, Pauline N. Wyrembak, Daniel B. Turner-Evans, Andrew D. Hamilton, David A. LaVan, Tarek M. Fahmy () and Mark A. Reed ()
Additional contact information
Eric Stern: Yale University
James F. Klemic: Yale University
David A. Routenberg: Yale University
Pauline N. Wyrembak: Yale University
Daniel B. Turner-Evans: Yale University
Andrew D. Hamilton: Yale University
David A. LaVan: Yale University
Tarek M. Fahmy: Yale University
Mark A. Reed: Yale University

Nature, 2007, vol. 445, issue 7127, 519-522

Abstract: 'Microsniffer' technology Semiconducting nanowires have the potential to act as highly sensitive sensors for the detection of pathogenic microorganisms, without the need for a label on the pathogen. Practical miniature sensors would have applications in diagnostics, homeland security and basic research. Current technologies have not been widely adopted for various reasons, including the difficulty of integrating nanoscale devices into practical sensors. Now a team spanning five departments at Yale has developed a new approach to the problem. In a state-of-the-art (CMOS-compatible) system they create miniature, ultra-sensitive sensors that can detect specific unlabelled antibodies at concentrations below 100 femtomolar and are able to monitor the cellular immune response in 'real-time'.

Date: 2007
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DOI: 10.1038/nature05498

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