bicoid RNA localization requires specific binding of an endosomal sorting complex

Uwe Irion and Daniel St Johnston ()
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Uwe Irion: University of Cambridge
Daniel St Johnston: University of Cambridge

Nature, 2007, vol. 445, issue 7127, 554-558

Abstract: Fronting up Although bicoid mRNA, the anterior determinant of Drosophila, was the first localized determinant to be identified, it is unclear how it targets the anterior of the Drosophila egg. Uwe Irion and Daniel St Johnston have now identified the specificity factor that couples the RNA to the localization pathway as the ESCRT-II complex. ESCRT-II is involved in sorting proteins endocytosed from the cell surface into the degradation pathway, and also acts as a tumour suppressor. Localization of bicoid mRNA is independent of endosomal sorting, and as rat ESCRT-II also binds RNA, this novel function in mRNA localization appears to be conserved in mammals.

Date: 2007
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DOI: 10.1038/nature05503

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